Mark and his fiancée, human rights lawyer  Simone George, spoke at TED2018 in Vancouver about how to resolve the tension between acceptance and hope, something they had to try and figure out in the aftermath of Mark’s catastrophic spinal cord injury.

Amy Cuddy, whose TED talk about power posing earned her worldwide recognition and has over 47 million views, described Simone and Mark’s talk as “the most powerful, moving talk I have ever seen at TED” while TED curator Helen Walters described their talk as a “love letter to science”.

Watch TED Talk